Univariate ANOVA, Pearson/Spearman correlation analysis, and multivariate logistic regression analysis were employed to investigate the relationship between thyroid hormones, glucose variability, and DKD.<h4>Results</h4>The DKD group exhibited lower free triiodothyronine (FT3) levels compared to the non-DKD group. The gene discussed is TG; the disease is diabetic kidney disease.