Western blotting indicated the downregulation of SOD1 and GPX4 as well as upregulation of PTGS2 and ACLS4 in the T2DM group accompanied by increased levels of Fe<sup>2+</sup>, total iron, and Fe<sup>3+</sup>.<h4>Conclusion</h4>This study underscores oxidoreductase activity-related proteins, including ferroptosis-related proteins to be differentially expressed in ESRD combined with T2DM. The gene discussed is GPX4; the disease is type 2 diabetes mellitus.