<h4>Aims</h4>To evaluate the differences in xanthine oxidoreductase (XOR) activity, metabolomic profiles, markers of oxidative stress, and inflammatory factors between patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and healthy controls, as well as the correlations among these factors.<h4>Methods</h4>A case-control study was conducted involving 54 MASLD patients alongside 54 healthy controls who were matched for age, gender, and ethnicity. Here, XDH is linked to liver disorder.