Single-cell RNA sequencing was used to analyze uPAR expression in immune cells from healthy controls and from patients with HBV-related cirrhosis.<h4>Results</h4>SuPAR levels correlated with disease severity markers, including creatinine, bilirubin, albumin, international normalized ratio, MELD score, and hospitalization duration (all <i>p <</i>0.001). This evidence concerns the gene PLAUR and Cirrhosis.