The burst keywords include sex difference, heterozygote familial hypercholesterolemia, PCSK9, lipid peroxidation, fish oil, monoclonal antibody, insulin sensitivity, and gene, etc.<h4>Conclusion</h4>Research on CHD indicates that risk factors influencing lipid levels encompass sex, genetics, PCSK9, and lipid peroxidation. This evidence concerns the gene PCSK9 and familial hypercholesterolemia.