Clarifying shared molecular mechanisms may facilitate early detection and prevention strategies.<h4>Methods</h4>Proteomic data from the UK Biobank were analysed using the Olink proximity extension assay for seven CRC-associated proteins (TFF3, TFF1, AHCY, RETN, LCN2, SELE and CEACAM5) previously identified via machine learning. This evidence concerns the gene RETN and colorectal carcinoma.