CD4 and malaria: The median CD4 + cell count was significantly lower in PLHIV with severe malaria (150 [IQR: 90-204] cells/μL) compared to those with asymptomatic (304 [IQR: 189-476] cells/μL) (p = 0.018).<h4>Conclusion</h4>Compared to HIV negative, asymptomatic malaria was less frequent while severe malaria predominantly affects PLHIV with advanced immunosuppression, highlighting the importance of early detection and management of co-infection to reduce morbidity.