This study explores the anti-cancer effects and mechanisms of action of trichodermamide B in targeting catalase-induced apoptosis in prostate cancer cells.<h4>Methods</h4>The anti-prostate cancer activity of trichodermamide B was evaluated using multiple prostate cancer cell lines, including LNCaP, 22Rv1, PC-3, and DU145. This evidence concerns the gene CAT and Familial prostate cancer.