While HC showed significantly increased temporal artery diameter and middle cerebral artery flow velocity during atosiban administration, no significant vascular changes were observed in participants with migraine.<h4>Discussion</h4>Short-acting oxytocin receptor antagonism did not trigger migraine attacks, suggesting that acute suppression of oxytocin signaling alone is unlikely to trigger migraine under stable hormonal conditions. The gene discussed is OXT; the disease is migraine disorder.