Furthermore, A concomitant downregulation of p-p65 expression and its downstream effectors, such as the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), was also observed.<h4>Conclusion</h4>Our findings indicate that Grg3 confers protective effects in a murine model of imiquimod-induced psoriasis-like dermatitis. The gene discussed is IL6; the disease is skin disorder.