B4GALNT1 and posterior cortical atrophy: By integrating RNA-seq data from multiple clinical cohorts (TCGA and CPGEA) and performing biochemical validation, we identified beta-1,4-N-acetylgalactosaminyltransferase 4 (B4GALNT4) as a glycogene significantly associated with advanced pathological stages, higher Gleason scores, and poor prognosis in PCa patients.