Depressive-like behavior and memory performance were assessed, followed by determination of plasma corticosterone, reactive species levels, lipid peroxidation, antioxidant enzyme activities, neuroinflammatory mediators, and acetylcholinesterase (AChE) activity in the hippocampus and prefrontal cortex of mice.<h4>Results</h4>4-PSQ significantly reversed Aβ-induced depressive behavior and memory impairment. Here, ACHE is linked to memory impairment.