PEPD and Creutzfeldt Jacob disease: Therefore, the aim of the present study was to understand the Brazilian PrD surveillance system.<h4>Methods</h4>This is a retrospective and descriptive study based on the epidemiological records of CJD surveillance from 2005 to 2021 in the Ministry of Health's Epidemiological Bulletin published in 2022.<h4>Results</h4>1,576 suspected cases of CJD were reported, concentrated in the Southeast, South and Northeast regions of Brazil.