Kaplan-Meier survival and Cox proportional hazards models were used to assess 1-year mortality, and restricted cubic spline analysis was conducted to explore nonlinear associations between TF activity and mortality.<h4>Results</h4>Among 135 patients with AC and AIS in the SCAN study database, 84 had available TF activity data. The gene discussed is TF; the disease is androgen insensitivity syndrome.