<h4>Introduction</h4>Insulin resistance is a complex metabolic disorder that involves multiple molecular pathways to disrupt insulin signaling and is associated with systemic complications.<h4>Methodology</h4>We searched through the literature using databases such as PubMed and selected relevant published papers related to the topic of this review.<h4>Results</h4>We synthesized this review based on the relevant literature and found that neuromodulation can target neuroendocrine systems responsible for metabolic homeostasis to manage insulin resistance. This evidence concerns the gene INS and Other metabolic disease.