INS and metabolic disease: <h4>Introduction</h4>Insulin resistance is a complex metabolic disorder that involves multiple molecular pathways to disrupt insulin signaling and is associated with systemic complications.<h4>Methodology</h4>We searched through the literature using databases such as PubMed and selected relevant published papers related to the topic of this review.<h4>Results</h4>We synthesized this review based on the relevant literature and found that neuromodulation can target neuroendocrine systems responsible for metabolic homeostasis to manage insulin resistance.