Mechanistic analysis revealed enhanced dendritic cell maturation (8-fold increase in CD11c<sup>+</sup> cells) and T-cell priming (2.3-fold increase in CD8<sup>+</sup> T cells) in tumor-draining lymph nodes (TDLNs), and CTL-mediated cytotoxicity (5.4-fold increase in CD107a<sup>+</sup> activated CTLs) in TME. The gene discussed is CD8A; the disease is neoplasm.