These findings may be relevant to a subset of human AITL cases since we found that ~20-30% of AITL patient samples have concomitantly elevated expression of <i>CXCR6</i>, <i>IL-18R1</i>, and <i>IFNG</i>.<h4>Conclusions</h4>Our study identified a pathogenic Tfh-like subset essential for AITL tumor progression in a mouse model and suggests that identifying and targeting a DE Tfh-like subset in AITL patients might be an effective strategy. This evidence concerns the gene CXCR6 and angioimmunoblastic T-cell lymphoma.