CXCR6 and neoplasm: However, it remains unclear if the Tfh-like cell populations contain a subset that drives tumor progression and, if so, whether such a subset may have druggable targets.<h4>Methods</h4>Through single-cell transcriptome analysis of Tfh-like cells isolated from the spontaneously arising AITL-like tumors in <i>Roquin<sup>san/+</sup></i> mice, we identified and characterized a tumor-enriched Tfh cell subset highly expressing CXCR6 and IL-18 receptor, termed "Double-Expressor (DE) Tfh" cells.