This study evaluated the diagnostic performance of a combined SDC2/SFRP2/TFPI2 gene methylation stool DNA test for detecting colorectal cancer (CRC) and advanced adenoma (AA).<h4>Methods</h4>A multicenter, case-control study was conducted involving 409 patients with CRC, 82 patients with AA, and 495 control participants between July 2022 and March 2024. Here, SDC2 is linked to colorectal cancer.