In addition, ZINC000101867325 is also predicted to target FGFR2 mutations in colorectal cancer patients.<h4>Conclusion</h4>We predicted three small molecules targeting FGFRs, and ZINC000101867325 shows superior chemical bond types and stability with FGFR1/2/3, and inhibits FGFR signaling in CRC cell lines. The gene discussed is FGFR2; the disease is colorectal cancer.