ERBB2 and breast cancer: The combination of CUS, CEUS, and SRUS achieved the highest area under the curve (AUC) of 0.976, with sensitivity, specificity and accuracy of 95.7%, 93.9% and 94.4%, respectively.<h4>Conclusions</h4>Multimodal ultrasound parameters from CUS, CEUS, and SRUS can predict HER2-positive breast cancer, and their combination provides superior diagnostic efficacy.