TNF and familial dilated cardiomyopathy: Bioinformatics analysis identified nine hub genes, which, according to Kyoto Encyclopedia of Genes and Genomes enrichment analysis, were mainly involved in "IL-17 signaling pathway," "TNF signaling pathway," "apoptosis" and "necroptosis." Aerobic exercise improved the heart function and myocardial enzymes of the rats in the DCM group, reduced myocardial damage, and inhibited fibrosis and OS.