Further confirmation using western blotting suggested that aerobic exercise may improve DCM by activating the PROC/proteinase-activated receptor 1 (PAR1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. The gene discussed is F2R; the disease is familial dilated cardiomyopathy.