Consensus clustering on 184 MDD-correlated genes stratified each CVD into two reproducible subtypes: a "homeostatic/pro-fibrotic" cluster enriched for ribosomal and cell-cycle pathways and an "inflammatory-metabolic" cluster characterized by NF-κB, TNF-α, IL-6, complement and coagulation activation.<h4>Conclusions</h4>Genetic, epidemiological, and multi-omic evidence supports a directional association between MDD and increased risk of MI and HF. This evidence concerns the gene NFKB1 and hydrops fetalis.