To identify patient subgroups based on autoantibody profile, unsupervised clustering was employed.<h4>Results</h4>SLE patients showed significantly elevated IFNα(p<0.001), IFNγ(p=0.009), and IFNλ3(p<0.001) levels as well as IFN score(p<0.001) as compared to healthy controls. Here, IFNL3 is linked to systemic lupus erythematosus.