Zinc finger protein ZIC2 plays a dual role in various cancers; however, its clinical value of ZIC2 in CRC remains unclear.<h4>Methods</h4>TCGA cohort data, GEO datasets (GSE39582 and GSE139555), and a CRC_10x spatial transcriptomics dataset were used for molecular feature analysis of ZIC2 to confirm its expression and clinical significance in cancer. The gene discussed is ZIC2; the disease is cancer.