Importantly, treatment with phthalic acid, a QPRT inhibitor, partially reversed the ZIC2-induced enhancement of cell migration, indicating that ZIC2 promotes CRC cell migration through a QPRT-dependent mechanism.<h4>Conclusion</h4>ZIC2 may serve as a valuable prognostic and prognostic biomarker in pan-cancer, including CRC. Here, ZIC2 is linked to cancer.