TLR4 and Parkinson disease: This study aims to explore the structural changes in the composition of the gut microbiota and the alterations in the inflammatory response mediated by the TLR4/NF-κB pathway in a rotenone-induced PD mouse model, as well as the correlation between the two.<h4>Methods</h4>The motor coordination and spontaneous locomotor activity of the PD mouse model were evaluated using the Rota-Rod test, pole climbing test and open field test.