This study aimed to investigate the role of the ALKBH5/PAX-8/ABCA1 pathway in C18-3OH-mediated regulation of macrophage cholesterol efflux and atherosclerosis and explore novel mechanisms of ABCA1 regulation from the perspective of m6A modification.<h4>Methods</h4>RT-qPCR and Western blotting were used to detect gene and protein expression, respectively. This evidence concerns the gene PAX8 and atherosclerosis.