CD274 and cholangiocarcinoma: <h4>Objective</h4>To compare overall survival (OS) and progression-free survival (PFS) between surgical resection and non-surgical therapy in initially unresectable Cholangiocarcinoma (CCA) patients who achieved radiologic/MDT-confirmed resectability after PD-1/PD-L1 inhibitors plus TKIs.<h4>Methods</h4>We performed a retrospective analysis of 47 patients with initially unresectable CCA admitted between June 2020 and December 2024.