GSEA demonstrated enrichment of several well-known malignancy-related gene sets in the high-risk group, including E2F target genes, MYC targets, mitotic spindle, and hypoxia-related pathways, among others.<h4>Conclusions</h4>A prognostic model based on m<sup>6</sup>A-related genes was developed, which exhibits strong efficacy in predicting the prognosis of osteosarcoma. This evidence concerns the gene MYC and osteosarcoma.