MRC1 and Ureteral obstruction: CD206<sup>+</sup> macrophages have emerged as key drivers of fibrogenesis, yet targeted strategies against this subset remain undeveloped.<h4>Methods</h4>Using human ureteropelvic junction obstruction (UPJO) tissues and a murine unilateral ureteral obstruction (UUO) model, we assessed the accumulation of CD206<sup>+</sup> macrophages and the progression of fibrosis.