qPCR confirmed increased PKD1 and SLC2A4 mRNA expression in RA compared with healthy controls.<h4>Discussion</h4>This integrative multi-omics MR framework supports an epigenetically mediated contribution of glycolysis-related regulation to RA susceptibility and nominates PKD1 and SLC2A4 as robust genetically supported candidate genes. The gene discussed is PKD1; the disease is rheumatoid arthritis.