Notably, hypomethylation at cg07036112 (PKD1; OR = 0.68, 95% CI: 0.59-0.78) and cg06891043 (SLC2A4; OR = 0.92, 95% CI: 0.89-0.96) was associated with increased gene expression and increased RA susceptibility. The gene discussed is SLC2A4; the disease is rheumatoid arthritis.