However, the precise mechanisms by which ALMS1 regulates metabolic and cardiovascular function remain unclear.<h4>Aim</h4>In this study, we investigate metabolic and cardiovascular functions regulated by ALMS1.<h4>Methods</h4>To investigate this, we developed and characterized an Alms1 knockout (KO) rat model, which spontaneously develops metabolic syndrome and hypertension.<h4>Results</h4>Our findings reveal that Alms1 KO rats exhibit age-dependent metabolic dysfunction, with hypertension and increased body weight becoming evident by 10-12 weeks of age. The gene discussed is ALMS1; the disease is metabolic syndrome.