NAPSA and neoplasm: To further delineate tumor intrinsic links between the epigenomic and expression phenotypes, 62 LUAD cell lines classified into the four epitypes were investigated and recapitulated several characteristics from the tumor epitypes, such as methylation and expression pattens of NAPSA/surfactant genes, highlighting epigenetic states as likely drivers or maintainers of broad tumor phenotypes and differentiation states.