Transcriptome-based analyses showed that AGTRAP expression was associated with a myeloid/macrophage-enriched microenvironment, and exploratory analyses suggested cross-tumor associations between AGTRAP expression and checkpoint blockade outcomes.<h4>Conclusion</h4>AGTRAP supports glioma cell survival by engaging an IL-6-linked JAK2/STAT3 program and is associated with a macrophage-rich, inflammatory tumor microenvironment. This evidence concerns the gene JAK2 and central nervous system cancer.