IL5RA and neoplasm: In the hypereosinophilic leukemia mouse model, a single infusion of hIL-5 CAR-T cells significantly reduced tumor burden and extended survival, demonstrating its therapeutic potential.<h4>Conclusions</h4>IL-5 CAR-T cell therapy represents a promising targeted therapeutic approach for IL-5Rα<sup>+</sup> hypereosinophilic disorders.