Increased respiratory effort during sleep innately correlates with sleep-disordered breathing/OSA related to allergies, especially the coexistence of respiratory and non-IgE mediated allergies, and is on the origin of the sleep fragmentation of children suffering OSA-asthma/associated, even if AHI remains in low levels; decreases (as AHI) with AT or ED, and if untreated, contributes to AHI increase, thus favoring the persistence of OSA and its comorbidities (hyperactivity, decrease in school performance, behavior/concentration problems) asthma and obesity. The gene discussed is IGHE; the disease is Allergy.