This study investigates the expression of LAG-3 in the TME of cervical cancer and its regulatory role in CD8<sup>+</sup> T cell function.<h4>Methods</h4>Cervical tissue pathological sections and fresh cervical tissues were collected from patients with cervical cancer, patients with high-grade squamous intraepithelial lesion (HSIL), and patients who underwent hysterectomy for non-cervical diseases (without a history of other tumors). This evidence concerns the gene LAG3 and squamous cell intraepithelial neoplasia.