HNF4A and hepatocellular carcinoma: CZ-2401 effectively stabilizes HNF4<i>α</i> protein in HCC cells and ameliorates TRIM47-driven HCC progression <i>in vivo.</i> Taken together, our research elucidates that targeting TRIM47-HNF4<i>α</i> interaction is a potential therapeutic strategy for HCC, and identifies CZ-2401 as a potent inhibitor of HNF4<i>α</i> degradation and a promising candidate for HCC therapy.