CRP and obesity due to melanocortin 4 receptor deficiency: <h4>Background</h4>The rising global challenges of obesity and chronic inflammation contribute to an increased prevalence of metabolic disorders and cardiovascular diseases.<h4>Objective</h4>The goal of the meta-analysis of randomized controlled trials (RCTs) was to assess the impact of yacon consumption on body weight and levels of C-reactive protein (CRP).<h4>Methods</h4>Online databases such as PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched until June 2024 to collect RCTs that investigated the impact of yacon consumption on body weight and CRP.