<h4>Background</h4>The rising global challenges of obesity and chronic inflammation contribute to an increased prevalence of metabolic disorders and cardiovascular diseases.<h4>Objective</h4>The goal of the meta-analysis of randomized controlled trials (RCTs) was to assess the impact of yacon consumption on body weight and levels of C-reactive protein (CRP).<h4>Methods</h4>Online databases such as PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched until June 2024 to collect RCTs that investigated the impact of yacon consumption on body weight and CRP. This evidence concerns the gene CRP and metabolic disease.