<h4>Objective</h4>This study evaluated the effects of intravitreal injection of antivascular endothelial growth factor (VEGF) treatment on visual acuity and macular edema severity in patients with comorbid hypertension and diabetes macular edema in China.<h4>Method</h4>A longitudinal observational study, involving a total of 89 cases with macular edema who received anti-VEGF injection treatment, compared the changes in visual acuity and macular edema severity among four groups of patients at three different time points. Here, VEGFA is linked to diabetic macular edema.