This increased TLR7 activation promotes keratinocyte hyperproliferation and dysregulated differentiation, and alters the M1/M2 macrophage balance, leading to elevated production of cytokines, including TNF-α and IL-6.<h4>Conclusion</h4>GPR108 functions as a negative regulator of TLR7 signaling in psoriasis. The gene discussed is GPR108; the disease is psoriasis.