This study aims to investigate the role of G protein-coupled receptor 108 (GPR108) in regulating TLR7 activity during imiquimod (IMQ)-induced psoriasiform dermatitis.<h4>Methods</h4>We established IMQ-induced psoriasiform lesions in Gpr108-null mice, as well as IMQ-treated GPR108-deficient keratinocyte and macrophage models. Here, GPR108 is linked to Psoriasiform dermatitis.