This study investigated the correlation between RA and Tumor necrosis factor α-induced protein 3 (TNFAIP3), Interleukin-1 receptor-associated kinase 1 (IRAK1), and Toll-like receptor 4 (TLR4) gene polymorphisms.<h4>Methods</h4>A sample of 308 RA cases and 310 matched controls was included. Here, TLR4 is linked to rheumatoid arthritis.