TLR4 and rheumatoid arthritis: Individuals carrying the rs5029939 C allele (OR = 2.401, 95% CI: 1.436-4.017, p = 0.001) of TNFAIP3, individuals carrying the rs7873784 C allele (OR = 1.549, 95% CI: 1.101-2.179, p = 0.012), and CG genotype (OR = 1.489, 95% CI: 1.011-2.193, p = 0.043) of TLR4 had a higher RA risk.<h4>Conclusion</h4>In summary, the TNFAIP3, IRAK1, and TLR4 gene polymorphisms are associated with RA susceptibility.