Similarly to CA 19-9 and CA 125, the serum OPN levels were higher in patients with pancreatic cancer when compared to controls, 3.37 (1.84; 9.12) ng/mL versus 1.59 (1.09; 2.51) ng/mL; <i>p</i> = 0.003. This evidence concerns the gene SPP1 and familial pancreatic carcinoma.