In keratinocytes, BMRGs such as integrins (<i>ITGB1</i>, <i>ITGA3</i>, <i>ITGA6</i>), laminins (<i>LAMA3</i>, <i>LAMC1</i>), <i>CD44</i>, and <i>FN1</i> were upregulated in cSCC compared to AK or BD (adjusted <i>p</i> < 0.05); in fibroblasts, BMRGs including <i>ITGB1</i>, <i>ITGAV</i>, <i>LUM</i>, <i>BGN</i>, <i>SDC1</i>, and <i>FN1</i> were upregulated in cSCC (adjusted <i>p</i> < 0.05), suggesting their collective role in BM breaching and invasion, as well as a higher risk of BD. Here, LAMC1 is linked to Behcet disease.