STAT3 and non-small cell lung carcinoma: Molecular docking studies of S2-4/NLRP3 and S2-14/STAT3, combined with the structure-activity relationship (SAR) analysis, indicated that the benzofuran core containing an <i>ortho</i>-quinone, along with an amide linkage and a 1,2,3-triazole group introduced at the C-2 position of the furan ring, is an effective chemical scaffold for enhancing the anti-NSCLC activity of tanshinone derivatives.