<b>Background/Objectives</b>: This study evaluated the diagnostic accuracy of cervical cytology, CINtec<sup>®</sup> (p16/Ki-67 dual staining), and PD-L1 immunohistochemistry, individually and in combination with high-risk HPV (HR-HPV) testing, for identifying histologically confirmed cervical lesions ranging from CIN1 to invasive carcinoma. The gene discussed is CD274; the disease is invasive carcinoma.