<b>Methods:</b> We analyzed demographic, clinical, functional (FEV<sub>1</sub>, FVC, FEV<sub>1</sub>/FVC), and immunological data (specific IgE for Phl p1, Phl p5, Der p1, Der p2, Der p23), alongside asthma control parameters (ACT score), reliever use, and exacerbation frequency, in patients undergoing SLIT for grass pollen and dust mite allergens. Here, IGHE is linked to asthma.