<b>Methods</b>: Variants in PD-L1 gene <i>CD274</i> (rs4143815, rs822336), and miR-155 gene <i>MIR155HG</i> (rs767649, rs1893650), assessed by TaqMan assays in 99 DLBCL patients and 113 age- and sex-matched healthy controls, were associated with clinicopathological features, treatment response, overall survival (OS), relapse-free survival (RFS), and disease susceptibility. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.