MKI67 and neoplasm: Immunohistochemistry confirmed elevated Ki-67 in tumors containing 3D-primed ADSCs, while macrophage infiltration (F4/80<sup>+</sup>) was highest in 2D-primed tumors and lowest in 3D-primed tumors.<h4>Conclusions</h4>Dimensional priming fundamentally reprograms ADSC phenotype and alters their stromal-immune interactions, generating a tumor-permissive state that accelerates PDAC progression.