Recurrent insertions were located near cancer-associated genes, including <i>RB1</i>, <i>NEDD4</i>, <i>FTO</i>, <i>LAMA2</i>, <i>NOD1</i>, and <i>KCNB2</i>, implicating LINE-1 activity in cis-regulatory remodeling of oncogenic pathways. Here, NEDD4 is linked to cancer.