Three key genes-WAS, ARHGAP30, and PARVG-were associated with metastasis, Huvos grade, and macrophage-specific expression and served as potential prognostic biomarkers.<h4>Conclusion</h4>This study highlights the prognostic and therapeutic relevance of immune infiltration in osteosarcoma. The gene discussed is ARHGAP30; the disease is osteosarcoma.